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The stem directly under the head dies, it turns color about three weeks before harvest.. That is when the plant is no longer feeding the kernals, that is when spraying could be done.

There was a north Dakota extension agent video, or pioneer video where a plant pathologists talked about round up timing.. When the stem below the head dies, the plant is done. Kind of like black layer on corn kernals... Once that happens you can safely spray it.
 
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